A united team of investigators has designed a nanoscale.
An individual dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas In a dramatic demonstration of the charged power of nanotechnology, a united team of investigators has designed a nanoscale, polymeric drug delivery vehicle that when loaded with a trusted anticancer agent cures colon cancer in mice with a single dose. The researchers, led by Francis Szoka, Ph.D tadalafil .D., of the University of California, Berkeley, published the results of the experiments in the Proceedings of the National Academy of Sciences USA.
Prof. Erdmann explained that the peroxisomal protein import machinery needs to be assembled prior to the peroxisome can import the numerous enzymes required. The Pex3p protein is a decisive factor for importing membrane proteins, functioning as docking site on the membrane. These docking sites enable targeted insertion of recently formed proteins. To date, it provides still not been completely clarified how Pex3p per se is integrated into the membrane. It could, however, be shown that recently formed Pex3p is in the beginning integrated in the cellular liquid of the endoplasmic reticulum . The subsequent mode of transport of Pex3p to the peroxisomes continues to be unknown. Prof. Erdmann mentioned that there is a big change between this pathway and that of other peroxisomal membrane proteins.