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Main Package mutations occur in approximately 85 % of individuals with GIST. The most common mutation is definitely on exon 11 . Preclinically, ponatinib demonstrated compelling activity against activating exon 11 mutations. These initial data support the preclinical results that ponatinib has activity against the obtained mutations in Package which individuals with GIST can develop following treatment with additional targeted TKIs, mentioned Michael C. Heinrich, M.D., professor of medicine and cell/developmental biology at the Knight Cancers Institute, Oregon Health & Research University, Portland, Oregon.Main Package mutations occur in approximately 85 % of individuals with GIST. The most common mutation is definitely on exon 11 . Preclinically, ponatinib demonstrated compelling activity against activating exon 11 mutations. These initial data support the preclinical results that ponatinib has activity against the obtained mutations in Package which individuals with GIST can develop following treatment with additional targeted TKIs, mentioned Michael C. Heinrich, M.D., professor of medicine and cell/developmental biology at the Knight Cancers Institute, Oregon Health & Research University, Portland, Oregon.