In the July issue of CHEST According to a 20-year study published.
Patients at least 20 years old upon enrollment were initially assessed for asthma, allergy symptoms, and potential confounders, including age, sex, and smoking position. Of the patients, 192 currently had asthma , 156 had been previously diagnosed with asthma but no longer experienced symptoms , and the rest of the patients didn’t have asthma. All individuals had negative findings for persistent bronchitis and emphysema at preliminary survey. Over the next twenty years, 12 periodic follow-up lung and surveys function testing were administered. Study outcomes showed that sufferers with active asthma were 10 times more likely to obtain symptoms of chronic bronchitis, 17 times much more likely to receive a medical diagnosis of emphysema, and 12.5 times more likely to build up COPD than sufferers without asthma.Two sufferers died of infection during the first year after transplantation. One individual had recurrent gram-adverse septicemia because of recurrent urinary tract attacks and died in a healthcare facility after he was contaminated by a nosocomial pathogen . The second patient had rapidly progressive, invasive pulmonary aspergillosis. Surgical resection was attempted, but the patient’s condition did not improve, and the patient died during the same admission. The 5th patient died of pulmonary squamous-cell carcinoma 5 years after transplantation. Allograft Rejection Eight episodes of biopsy-confirmed severe rejection occurred in five sufferers . Rejection prices were 8 percent at 12 months and 22 percent at three years. Six of the eight episodes of severe rejection were successfully reversed either by treatment with glucocorticoids or rabbit antithymocyte globulin or through plasmapheresis.